A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues
| Autor: | Licia Selleri, Benjamin Tycko, Floria Lupu, Frédéric Gilles, Andrew D. Zelenetz, Andre Goye, Yu-Hung Kuo, Ghassan J. Samara, Patricia Tsang, Luwa Yuan, Josh Moosikasuwan |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Ribosomal Proteins DNA Complementary RNA Untranslated Molecular Sequence Data Muscle Proteins Biology Methylation Mitochondrial Proteins Genomic Imprinting Exon Fetus Gene mapping Gene expression Genetics Humans Amino Acid Sequence RNA Messenger Epigenetics Cloning Molecular Gene Molecular Biology Alleles Genetics (clinical) Polymorphism Genetic Base Sequence Sequence Homology Amino Acid Gene Expression Regulation Developmental Proteins RNA-Binding Proteins DNA General Medicine Molecular biology female genital diseases and pregnancy complications embryonic structures DNA methylation RNA Long Noncoding Human genome Genomic imprinting |
| Zdroj: | Human Molecular Genetics. 4:2187-2188 |
| ISSN: | 1460-2083 0964-6906 |
| DOI: | 10.1093/hmg/4.11.2187 |
| Popis: | The closely linked IGF2 and H19 genes on human chromosome 11p15.5 are monoallelically expressed as a result of genomic imprinting and show altered expression in Wilms' tumors (WTs). To map regional imprinting we have sought to isolate additional human genes close to IGF2/H19 and to characterize their allelic expression patterns. Here we report a novel gene, provisionally named L23MRP [L23 (mitochondrial)-related protein], which is oriented 'tail-to-tail' with H19 and is transcribed to within 40 kb of the last H19 exon. L23MRP is expressed biallelically in many mid-fetal and adult human tissues. This gene is also expressed at normal levels in WTs which have lost expression of H19 either via loss of the maternal chromosome 11p15.5 or via an epigenetic pathway involving site-specific DNA hypermethylation. These data indicate that, at least in post-embryonic stages, L23MRP is functionally insulated from the IGF2/H19 imprinted domain. |
| Databáze: | OpenAIRE |
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