A case of acute and severe thrombocytopenia due to readministration of rifampicin
| Autor: | Yoshinobu Namba, Seigo Kitada, Yukihiro Yano, Toshihiko Yamaguchi, Kazutaka Izawa, Takeshi Uenami, Teppei Sugano, Masahide Mori, Soichiro Yokota, Ryoji Maekura, Tsutomu Yoneda, Hiromi Kimura, Takeya Fujikawa, Sin-ichi Kagami |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Tuberculosis Antitubercular Agents Neutropenia Severity of Illness Index Gastroenterology Tuberculosis Osteoarticular hemic and lymphatic diseases Internal medicine polycyclic compounds medicine Humans Pharmacology (medical) Platelet Ethambutol business.industry Isoniazid Humerus Middle Aged Pyrazinamide bacterial infections and mycoses medicine.disease Thrombocytopenia Surgery Infectious Diseases Platelet transfusion Acute Disease Female Rifampin business Rifampicin medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 17:288-290 |
| ISSN: | 1341-321X |
| Popis: | A 49-year-old-woman was diagnosed with tuberculosis of the left humerus. She had received treatment, including rifampicin, for tuberculosis 17 years previously. Treatment was begun with isoniazid, rifampicin, ethambutol, and pyrazinamide, but these were discontinued because of mild neutropenia and thrombocytopenia 2 weeks posttreatment. Rifampicin and ethambutol were readministered after a 4-day interruption; however, generalized purpura appeared several hours later. By the next day, her platelet count was reduced from 160 × 10(3) to 3 × 10(3)/μl. The patient improved rapidly after platelet transfusion and steroid treatment. Readministration of drugs other than rifampicin did not induce thrombocytopenia; therefore, thrombocytopenia was likely due to rifampicin. |
| Databáze: | OpenAIRE |
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