Structure–activity relationships of azasugar-based MMP/ADAM inhibitors

Autor:	Kohichiro Yoshino, Shin-Ichiro Nishimura, Hideki Moriyama, Yoshimasa Inoue, Takahiro Tsukida, Hirosato Kondo
Rok vydání:	2003
Předmět:	Stereochemistry Matrix metalloproteinase inhibitor Clinical Biochemistry Pharmaceutical Science ADAM17 Protein Matrix Metalloproteinase Inhibitors Matrix metalloproteinase Benzoates Gluconates Biochemistry Chemical synthesis Lactones Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Structure–activity relationship Protease Inhibitors Molecular Biology chemistry.chemical_classification Aza Compounds Hydroxamic acid biology Chemistry Phenyl Ethers Organic Chemistry Metalloendopeptidases Stereoisomerism ADAM Proteins Kinetics Enzyme Enzyme inhibitor Drug Design biology.protein Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:2737-2740
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00530-4
Popis:	In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9963940fc5f5e2df0676bf362146f660 https://doi.org/10.1016/s0960-894x(03)00530-4 Zobrazit plný text záznamu Full Text from ScienceDirect