Metabolism of oral glucose in children born small for gestational age: evidence for an impaired whole body glucose oxidation

Autor: François R Jornayvaz, Luc Tappy, Roxane Selz, Gérald Theintz
Rok vydání: 2004
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Adolescent
Body Composition/physiology
Endocrinology
Diabetes and Metabolism
Body Height/physiology
Adipose tissue
Intrauterine growth restriction
Energy Metabolism/physiology
Endocrinology
Insulin resistance
Oral administration
Internal medicine
medicine
Glucose/metabolism
Humans
Fetal Growth Retardation/metabolism
Young adult
Child
Fetal Growth Retardation
Blood Glucose/metabolism
business.industry
Body Weight
Infant
Newborn
Infant
Type 2 Diabetes Mellitus
Newborn
Lipid Metabolism
medicine.disease
Body Height
Glucose
Adipose Tissue
El Niño
Body Weight/physiology
Adipose Tissue/physiology
Infant
Small for Gestational Age
Body Composition
Small for gestational age
Female
Small for Gestational Age/metabolism
Energy Metabolism
business
Oxidation-Reduction
Zdroj: Metabolism, Vol. 53, No 7 (2004) pp. 847-51
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2004.02.003
Popis: Epidemiological studies indicate that intrauterine growth restriction confers an increased risk of developing type 2 diabetes mellitus in subsequent life. Several studies have further documented the presence of insulin resistance in young adults or adolescent children born small for gestational age. Since most studies addressed postpubertal individuals, and since puberty markedly affects energy metabolism, we evaluated the disposal of oral glucose in a group including mainly prepubertal and early pubertal children with intrauterine growth restriction and in healthy age- and weight-matched control children. All children had an evaluation of their body composition by skinfold thickness measurements. They were then studied in standardized conditions and received 4 consecutive hourly loads of 180 mg glucose/kg body weight to reach a near steady state. Energy expenditure and substrate oxidation were evaluated during the fourth hour by indirect calorimetry. Compared to both age- and weight-matched children, children born small for gestational age had lower stature. Their energy expenditure was not significantly decreased, but they had lower glucose oxidation rates. These results indicate that metabolic alterations are present early in children born small for gestational age, and are possibly related to alterations of body composition.
Databáze: OpenAIRE
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