Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men
| Autor: | P. L. Dolan, N. Leggett-Frazier, Richard G. Israel, R. K. Bruner, M. H. Shinebarger, Joseph A. Houmard, G. L. Dohm, M. R. McCammon |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Senescence medicine.medical_specialty Monosaccharide Transport Proteins Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Muscle Proteins Physical exercise Physiology (medical) Internal medicine medicine Humans Insulin Pancreatic hormone Glucose Transporter Type 4 Physical Education and Training Chemistry Muscles Osmolar Concentration Skeletal muscle Middle Aged Glucose transporter protein Endocrinology medicine.anatomical_structure Carrier protein Body Composition Physical Endurance Energy Intake Protein concentration |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 264:E896-E901 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1993.264.6.e896 |
| Popis: | The purpose of this study was to determine if 14 wk of exercise training would increase insulin-sensitive glucose transporter protein (GLUT-4) concentration in skeletal muscle of previously sedentary middle-aged men (47.2 +/- 1.3 yr; n = 13). Muscle samples (lateral gastrocnemius) and insulin action [insulin sensitivity index (ISI), minimal model] were obtained in the sedentary condition and 48 h after the final training bout. GLUT-4 protein concentration increased (P < 0.001, 2,629 +/- 331 to 4,140 +/- 391 absorbance units/100 micrograms protein) with exercise training by 1.8-fold. ISI increased by twofold (P < 0.05, 2.1 +/- 0.5 to 3.4 +/- 0.7 SI x 10(5) min/pM) with training. The percentage of GLUT-4 rich type IIa muscle fibers increased by approximately 10% (P < 0.01), which may have contributed to the elevation in transporter protein. GLUT-4 concentration and citrate synthase activity (1.7-fold, P < 0.001) also increased by similar increments. These findings indicate that GLUT-4 protein concentration is elevated in middle-aged individuals with exercise training. |
| Databáze: | OpenAIRE |
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