The dynamic time course of semantic memory impairment in Alzheimer's disease: clues from hyperpriming and hypopriming effects
| Autor: | Francis Eustache, C. Lalevée, Vincent de La Sayette, Hélène Beaunieux, Bénédicte Giffard, Béatrice Desgranges, Florence Nore-Mary, Florence Pasquier |
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| Přispěvatelé: | Laboratoire de Neuropsychologie, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neurophysiologie et Neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Beaunieux, Helene |
| Rok vydání: | 2002 |
| Předmět: |
Male
Decision Making [SHS.PSY]Humanities and Social Sciences/Psychology Semantics Severity of Illness Index Superordinate goals 050105 experimental psychology Task (project management) [SHS.PSY] Humanities and Social Sciences/Psychology [SCCO]Cognitive science 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Memory Reference Values Reaction Time Lexical decision task Humans Verbal fluency test Semantic memory 0501 psychology and cognitive sciences Longitudinal Studies ComputingMilieux_MISCELLANEOUS Aged Language Aged 80 and over Memory Disorders Communication [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology business.industry [SCCO.NEUR]Cognitive science/Neuroscience [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology [SCCO.NEUR] Cognitive science/Neuroscience 05 social sciences [SCCO] Cognitive science Middle Aged Knowledge Female Neurology (clinical) Implicit memory Cues Psychology business Priming (psychology) 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Scopus-Elsevier Brain-A Journal of Neurology Brain-A Journal of Neurology, 2002, 125 (9), pp.2044-2057. ⟨10.1093/brain/awf209⟩ Brain-A Journal of Neurology, Oxford University Press (OUP), 2002, 125 (9), pp.2044-2057. ⟨10.1093/brain/awf209⟩ |
| ISSN: | 1460-2156 0006-8950 |
| DOI: | 10.1093/brain/awf209 |
| Popis: | The nature of semantic memory deficit in Alzheimer's disease is still a matter of controversy. To clarify this issue, we examined the evolution of semantic memory impairment in 24 Alzheimer's disease patients by means of a longitudinal study. We used two semantic tasks, one explicit and the other implicit, to evaluate the integrity of the same concepts. The explicit task was a semantic knowledge task composed of naming and questions, involving superordinate and attribute knowledge of concepts. The implicit task, a lexical decision task, assessed semantic priming and allowed a very pure measurement of semantic memory. In this task, related pairs of words had coordinate (e.g. "tiger-lion") or attribute ("tiger-stripe") relationships. In the coordinate relation between two words, the semantic priming performances were at first paradoxical: they increased abnormally (hyperpriming) before falling down, whereas in the attribute condition, the priming effects were first normal and then started to decrease in the final sessions (hypopriming). Compared with the semantic knowledge performance, these apparently disconcerting results reflect a coherent pattern of semantic memory degradation in Alzheimer's disease that is a progressive deterioration starting with specific attribute information. The data reveal in an astonishing yet striking manner the dynamic semantic memory degradation in Alzheimer's disease through the apparently paradoxical semantic priming effects. |
| Databáze: | OpenAIRE |
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