Carotid endarterectomy and gliofibrillar S100b protein release

Autor: R. Perna, M. G. Reale, F. Benedetti Valentini, V. Di Piero, R. Gattuso, F. Di Stani, S. Di Legge, Gian Luigi Lenzi
Rok vydání: 2003
Předmět:
Brain Infarction
Carotid Artery Diseases
Male
medicine.medical_specialty
Neurology
medicine.medical_treatment
Hemodynamics
S100 Calcium Binding Protein beta Subunit
Dermatology
Carotid endarterectomy
Brain Ischemia
Brain ischemia
Postoperative Complications
Predictive Value of Tests
Internal medicine
Carotid artery disease
medicine
Humans
Nerve Growth Factors
Cognitive decline
Stroke
pathophysiology
Aged
Endarterectomy
Aged
80 and over
Endarterectomy
Carotid
business.industry
S100 Proteins
Brain
General Medicine
Middle Aged
medicine.disease
Adaptation
Physiological
Up-Regulation
Causality
Psychiatry and Mental health
Carotid Arteries
brain ischemia
carotid endarterectomy
gliofibrillar s100b protein
Ischemic Attack
Transient
Cerebrovascular Circulation
Cardiology
Female
Neurology (clinical)
Tomography
X-Ray Computed
business
Biomarkers
Zdroj: Neurological Sciences. 24:351-356
ISSN: 1590-3478
1590-1874
DOI: 10.1007/s10072-003-0188-x
Popis: Increased levels of the gliofibrillar S100b protein can be detected during carotid endarterectomy (CEA). Whether the S100b protein increase is marker of brain ischemic sufferance and predictor of cognitive decline is controversial. Twenty-eight patients underwent clinical assessment and cranial computed tomography (CT) 24-48 hours before and 3 months after CEA. S100b serum levels were evaluated before surgery, at cross-clamping, 10 minutes later, at declamping, and 24-48 hours and 10-12 weeks after CEA. Increased S100b levels were detected in 11 patients (39%); eight (73%) of these patients had symptomatic carotid artery disease. Increased S100b level correlated with history of TIA or stroke ( p=0.005), low mini-mental state examination score ( p=0.02), and ischemic infarctions at preoperative CT ( p=0.03). Slight and transient increased S100b levels were detected in 39% of patients during CEA. The protein levels increased despite the absence of clinical events during surgery. Our findings suggest a failure of compensatory hemodynamic or metabolic mechanisms in peri-ischemic tissue, whose longterm effects on cognition remain to be investigated.
Databáze: OpenAIRE
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