Fetal Ultrasound and Magnetic Resonance Imaging Findings in Suspected Septo‐Optic Dysplasia
| Autor: | Shira L. Robbins, Rebecca Rakow-Penner, Dolores H. Pretorius, Paritosh C. Khanna, Neda Ghassemi, Andrew D. Hull, Jeffrey Gold, Amy Maduram, Nikdokht Farid |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Prenatal diagnosis Ultrasonography Prenatal 030218 nuclear medicine & medical imaging 03 medical and health sciences Lateral ventricles 0302 clinical medicine Septo-Optic Dysplasia Pregnancy medicine Humans Radiology Nuclear Medicine and imaging Retrospective Studies Optic nerve hypoplasia Fetus 030219 obstetrics & reproductive medicine Radiological and Ultrasound Technology medicine.diagnostic_test business.industry fungi Ultrasound Infant Newborn Magnetic resonance imaging Septo-optic dysplasia medicine.disease Magnetic Resonance Imaging Dysplasia Female Septum Pellucidum Radiology business |
| Zdroj: | Journal of Ultrasound in Medicine. 39:1601-1614 |
| ISSN: | 1550-9613 0278-4297 |
| DOI: | 10.1002/jum.15252 |
| Popis: | Objectives To investigate prenatal imaging findings supporting a diagnosis of suspected septo-optic dysplasia (SOD) by fetal ultrasound (US), magnetic resonance imaging (MRI), or both. Methods A retrospective review identified 11 patients with SOD: 9 had a clinical diagnosis of SOD postnatally, and 2 were terminated on the basis of suspicious prenatal imaging. Prenatal and neonatal imaging of the cavum septi pellucidi (CSP), frontal horns (FHs), and lateral ventricles was evaluated. Results The appearance of the CSP varied on US and MRI. Complete ("fused") FHs or partial absence of the CSP was reported in 6 of 11 patients by fetal US and 7 of 8 patients by fetal MRI. The diagnosis of SOD was prospectively suspected prenatally in 6 of 11 and in an additional 5 of 11 cases retrospectively. Fetal MRI incorrectly initially reported normal morphologic abnormalities for 2 cases with partial absence of the CSP, whereas US accurately identified the morphologic abnormalities in 1 of these cases before MRI. Imaging features were first suggested at anatomic US (4 patients) and follow-up prenatal US (2 patients). Neonatal imaging was concordant in all 9 live births: 5 completely absent CSP, 3 partially absent CSP, and 1 completely present CSP. Clinical manifestations included optic nerve hypoplasia (9 of 9), panhypopituitarism (5 of 9), and neurodevelopmental delays. Conclusions Primary imaging features of SOD are "continuous" FHs with complete or partial absence of the CSP. Septo-optic dysplasia can be suspected in utero and can appear isolated but has substantial associated central nervous system anomalies identified on fetal MRI or after birth. Partial absence of the CSP can be a prenatal sign of suspected SOD, although fetal MRI lacked the spatial resolution to identify it accurately in all cases. |
| Databáze: | OpenAIRE |
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