A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin
| Autor: | Dharmendra Neupane, Keith J. Stine, Alexei V. Demchenko, Jay K. Bhattarai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Biocompatibility media_common.quotation_subject Supramolecular chemistry Pharmaceutical Science 02 engineering and technology macromolecular substances 030226 pharmacology & pharmacy Article 03 medical and health sciences 0302 clinical medicine medicine polycyclic compounds Doxorubicin media_common chemistry.chemical_classification Cyclodextrin Chemistry Nanoporous technology industry and agriculture 021001 nanoscience & nanotechnology Combinatorial chemistry Controlled release carbohydrates (lipids) Surface modification 0210 nano-technology medicine.drug |
| Zdroj: | J Drug Deliv Sci Technol |
| Popis: | This article reports a novel thiolated β-cyclodextrin (HS-β-CD) modified nanoporous gold (NPG) wire for pH sensitive delivery of doxorubicin (DOX) in controlled manner. Nanoporous gold is a versatile material because of its three-dimensional nanoscale network of pores, facile surface functionalization, biocompatibility, and high capacity for the DOX payload. HS-β-CD can form supramolecular inclusion complexes with DOX affording the possibility of altering the controlled release behavior. DOX is one of the most potent anti-tumor drugs used in the treatment of different cancers. The binding of HS-β-CD and DOX was examined using UV-Vis spectroscopy. The prepared NPG structure exhibited excellent properties for controlled drug release outlining the potential of a pH sensitive drug implant for biomedical applications. This delivery system could improve local targeting of the drug as well as alter the rate of release of DOX near tumors. |
| Databáze: | OpenAIRE |
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