Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

Autor:	Keisuke Kaneko, Christopher B. Currin, Kevin M. Goff, Eric R. Wengert, Ala Somarowthu, Tim P. Vogels, Ethan M. Goldberg
Rok vydání:	2021
Předmět:	NAV1.1 Voltage-Gated Sodium Channel Mice Parvalbumins Interneurons Animals Epilepsies Myoclonic Models Theoretical Synaptic Transmission General Biochemistry Genetics and Molecular Biology
Zdroj:	Cell reports. 38(13)
ISSN:	2211-1247
Popis:	Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAergic interneurons (PV-INs) from young Scn1a
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9960605095e4230eebbf3e9495d54ca9 https://pubmed.ncbi.nlm.nih.gov/35354025 Zobrazit plný text záznamu