Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma

Autor: Jinyou Li, Qiang Li, Feng Zhang, Jiayuan Jiang, Qi Sun, Yong Zhao, Zhenyu Su, Tienan Feng, Haitao Ma
Rok vydání: 2020
Předmět:
Adult
Male
Lung adenocarcinoma
0301 basic medicine
Fatty acid metabolic process
genetic structures
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Adenocarcinoma of Lung
Biology
Signature
Nomogram
Transcriptome
03 medical and health sciences
0302 clinical medicine
Endocrinology
Diagnosis
Biomarkers
Tumor
medicine
Humans
Insulin
Diacylglycerol O-Acyltransferase
Glucuronosyltransferase
Lung cancer
lcsh:RC620-627
Gene
Aged
Cytochrome P-450 CYP2C9
Research
Biochemistry (medical)
Lipid metabolism
Middle Aged
Gene signature
Prognosis
medicine.disease
Lipids
Gene Expression Regulation
Neoplastic
Intramolecular Oxidoreductases
Lipoprotein Lipase
lcsh:Nutritional diseases. Deficiency diseases
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Adenocarcinoma
Biomarker (medicine)
Female
Hub genes
Zdroj: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-9 (2020)
Lipids in Health and Disease
ISSN: 1476-511X
DOI: 10.1186/s12944-020-01390-9
Popis: BackgroundLung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD.MethodsIn this study, expression analysis of 1045 lipid metabolism-related genes was performed between LUAD tumors and normal tissues derived from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) cohort. The interaction network of differentially expressed genes (DEGs) was constructed to identify the hub genes. The association between hub genes and overall survival (OS) was evaluated and formed a model to predict the prognosis of LUAD using a nomogram. The model was validated by another cohort, GSE13213.ResultsA total of 217 lipid metabolism-related DEGs were detected in LUAD. Genes were significantly enriched in glycerophospholipid metabolism, fatty acid metabolic process, and eicosanoid signaling. Through network analysis and cytoHubba, 6 hub genes were identified, includingINS,LPL,HPGDS,DGAT1,UGT1A6, andCYP2C9. High expression ofCYP2C9,UGT1A6, andINS, and low expressions ofDGAT1,HPGDS, andLPL, were associated with worse overall survival for 1925 LUAD patients. The model showed that the high-risk score group had a worse OS, and the validated cohort showed the same result.ConclusionsIn this study, a signature of 6 lipid metabolism genes was constructed, which was significantly associated with the diagnosis and prognosis of LUAD patients. Thus, the gene signature can be used as a biomarker for LUAD.
Databáze: OpenAIRE
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