Inhibition of prolactin secretion by ergolines
| Autor: | E. Barrysmalstig, James A. Clemens, Bach Nicholas J, Carl Joseph Shaar, Kornfeld Edmund C |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Ergot Alkaloids Reserpine Peptide Biology chemistry.chemical_compound Endocrinology Internal medicine medicine Ergocryptine Animals Secretion Ergolines chemistry.chemical_classification Dose-Response Relationship Drug Dihydroergocornine Prolactin Ergoline Rats chemistry Female Dihydroergocryptine hormones hormone substitutes and hormone antagonists medicine.drug Ergocornine |
| Zdroj: | Endocrinology. 94(4) |
| ISSN: | 0013-7227 |
| Popis: | Peptide-containing ergot alkaloids and synthetic ergoline derivatives were administered to reserpine-treated male rats in order to evaluate their prolactin-inhibiting properties. Each compound was administered ip at a standard 50 ¼g/kg dose. The 9,10-dihydrogenated ergots, dihydroergocornine, and dihydroergocryptine were able to inhibit prolactin to the same degree as ergocornine and ergocryptine. This is significant because the 9,10-dihydrogenation process removes the toxic vasoconstrictive properties from the molecule and allows the prolactin-inhibiting ability to remain intact. In addition, dose-response studies show that minute amounts of an ergot can cause a significant reduction in prolactin secretion. The failure of ergocorninine to inhibit prolactin secretion demonstrates that the stereochemical configuration of the molecule at the 8 position is important for prolactin-inhibiting ability. Interestingly, a number of simple ergot molecules lacking the peptide side chain are able to inhibit prolactin... |
| Databáze: | OpenAIRE |
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