Calciphylaxis with evidence of hypercoagulability successfully treated with unfractionated heparin: a multidisciplinary approach
| Autor: | J. Barrett, A. Carter, J. R. Nunley, Alex G. Ortega-Loayza |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Hypercalcaemia Vessel occlusion Dermatology Disease Skin Diseases Metabolic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Thrombophilia Intensive care medicine Calciphylaxis Hyperparathyroidism Leg business.industry Heparin Anticoagulants Middle Aged medicine.disease Surgery Treatment Outcome 030220 oncology & carcinogenesis Etiology Female business medicine.drug Calcification |
| Zdroj: | Clinical and experimental dermatology. 41(3) |
| ISSN: | 1365-2230 |
| Popis: | Calciphylaxis is characterized by abnormal calcification of vessels and skin; however, its aetiology and pathogenesis remain unclear. Entities frequently associated with calciphylaxis are end-stage renal disease, diabetes mellitus, hypercalcaemia, hyperphosphataemia, elevated calcium-phosphate product, hyperparathyroidism and possible hypercoagulable states. Skin lesions may remain quiescent or may develop suddenly and progress rapidly. They are more common on the legs. Treatment of calciphylaxis is very challenging and requires interdisciplinary management. We present a case that highlights the difficulty of treating calciphylaxis. A multidisciplinary approach was vital for the proper treatment of our patient. This case also demonstrates the importance of searching for underlying hypercoagulable states, especially in recalcitrant cases. In cases of calciphylaxis with vessel occlusion from microthrombi, heparin therapy would be a logical next step. The effect of anticoagulation may be rapid and impressive. |
| Databáze: | OpenAIRE |
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