Existence of a polar digitalis-like factor in mammalian hypothalamus
| Autor: | Masaru Ishii, A. Goto, Chikahiko Eguchi, Kouichi Yamada, Tokuichiro Sugimoto, Masanori Yoshioka, Tsuneo Ishiguro |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Ouabain binding
Digoxin Erythrocytes Hypothalamus Biophysics Digitalis Kidney Binding Competitive Biochemistry Dogs medicine Animals Humans Na+/K+-ATPase Ouabain Molecular Biology Chromatography High Pressure Liquid biology Chemistry Biological activity Blood Proteins Cell Biology Saponins Rubidium biology.organism_classification Rats Cardenolides Kinetics Red blood cell medicine.anatomical_structure Enzyme inhibitor biology.protein Polar Cattle Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Biochemical and Biophysical Research Communications. 161:953-958 |
| ISSN: | 0006-291X |
| Popis: | We were able to partially purify a polar digitalis-like factor from rat and bovine hypothalami based on the capacity to inhibit [3H]ouabain binding to intact human erythrocytes. This factor was characterized in reference to the digitalis-like factor that we have isolated and reported on. Hypothalamic factor shared digitalis-like activities and physicochemical properties with the one derived from human urine and mammalian plasma. These findings strongly suggest that a polar digitalis-like factor identical to the circulatory factor does exist in mammalian hypothalamus. |
| Databáze: | OpenAIRE |
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