Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
| Autor: | Monica Moresco, Marco Filardi, Fabio Pizza, Vincenzo Donadio, Rocco Liguori, Luigi Ferini-Strambi, Alex Incensi, Stefano Vandi, Giuseppe Plazzi, Yuri L Sosero, Elena Antelmi, Sara Marelli, Raffaele Ferri |
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| Přispěvatelé: | Antelmi, E., Pizza, F., Donadio, V., Filardi, M., Sosero, Y. L., Incensi, A., Vandi, S., Moresco, M., Ferri, R., Marelli, S., Ferini-Strambi, L., Liguori, R., Plazzi, G., Antelmi, Elena, Pizza, Fabio, Donadio, Vincenzo, Filardi, Marco, Sosero, Yuri L, Incensi, Alex, Vandi, Stefano, Moresco, Monica, Ferri, Raffaele, Marelli, Sara, Ferini-Strambi, Luigi, Liguori, Rocco, Plazzi, Giuseppe |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Biopsy Polysomnography REM sleep behavior disorder Neurosciences. Biological psychiatry. Neuropsychiatry narcolepsy REM Sleep Behavior Disorder Brief Communication Gastroenterology RBD 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans biomarkers RC346-429 Pathological Aged Skin medicine.diagnostic_test business.industry General Neuroscience NARCOLEPSY Middle Aged medicine.disease Pathophysiology 030104 developmental biology BIOMARKERS REM SLEEP BEHAVIOR DISORDER Skin biopsy Sleep behavior alpha-Synuclein Female Neurology. Diseases of the nervous system Neurology (clinical) Corrigendum business Brief Communications 030217 neurology & neurosurgery Biomarkers RC321-571 Narcolepsy |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1872-1876 (2019) |
| Popis: | To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α‐synuclein deposits and whole‐night video‐polysomnography. Skin biopsy was positive for phosphorylated α‐synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video‐polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology. |
| Databáze: | OpenAIRE |
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