Cardioprotective Effect of Edaravone against Ischaemia–Reperfusion Injury in the Rabbit Heart Before, during and after Reperfusion Treatment
| Autor: | K Harafuji, Yujirou Tanabe, H Shiobara, Manabu Fujinawa, Yachiyo Hoshiba, Y Kobori, Toyoyuki Okubo, Akihiro Fukuda, Shinji Okubo, Akira Yamashina |
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| Rok vydání: | 2006 |
| Předmět: |
Cardiotonic Agents
Time Factors Drug Evaluation Preclinical Myocardial Infarction Infarction Apoptosis Myocardial Reperfusion Injury Prostacyclin DNA Fragmentation 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound Lipoxygenase 0302 clinical medicine Edaravone Animals Medicine biology business.industry Biochemistry (medical) Free Radical Scavengers Cell Biology General Medicine medicine.disease Free radical scavenger chemistry 030220 oncology & carcinogenesis Anesthesia biology.protein Arachidonic acid Rabbits business Reperfusion injury Antipyrine medicine.drug |
| Zdroj: | Journal of International Medical Research. 34:475-484 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000603400504 |
| Popis: | The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia–reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect. |
| Databáze: | OpenAIRE |
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