Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis
| Autor: | Richard K. Scher, Amir Tavakkol, Norifumi Nakamura |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Antifungal
medicine.medical_specialty Antifungal Agents Nail Infection medicine.drug_class Administration Topical Luliconazole Topical treatment Dermatology Trichophyton rubrum Pharmacology medicine.disease_cause chemistry.chemical_compound Onychomycosis medicine Humans Foot Dermatoses integumentary system biology Imidazoles General Medicine Nail plate biology.organism_classification Pharmaceutical Solutions Infectious Diseases medicine.anatomical_structure chemistry Nail (anatomy) Dermatophyte |
| Zdroj: | Mycoses. 57:389-393 |
| ISSN: | 0933-7407 |
| Popis: | Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections. |
| Databáze: | OpenAIRE |
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