Influence of a standard meal on the absorption of a controlled release pseudoephedrine suspension
| Autor: | Graves Da, Lewis P. Amsel, Meyer Mc, Bhargava Ak, Straughn Ab, Wecker Mt, Hinsvark On, Rotenberg Ks |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Ephedrine Male Pharmacology Chromatography Adolescent Chemistry digestive oral and skin physiology Cmax Pharmaceutical Science General Medicine Pseudoephedrine Controlled release Dosage form Nasal decongestant Postprandial Pharmacokinetics Food Delayed-Action Preparations Anesthesia medicine Humans Pharmacology (medical) medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 9:267-272 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bod.2510090305 |
| Popis: | The influence of a standard meal on the extent and rate of absorption of pseudoephedrine from a liquid controlled release (CR) formulation (Pennkinetic System) was studied in 16 normal male volunteers. Equivalent single doses of an immediate release reference syrup (IR-Sudafed) and the CR suspension were each studied under both fasted and postprandial conditions. AUC results showed no significant influence of food or formulation, indicating that the CR formulation was absorbed to the same extent as the IR product under all conditions. CMAX and TMAX tabulations under fasted conditions indicated that the CR preparation peaked at a lower level at a later time. Food diminished IR CMAXs but the CR suspension's CMAXs and TMAXs were apparently unaffected by food. This study indicates that this CR pseudoephedrine suspension releases drug independently of food intake. |
| Databáze: | OpenAIRE |
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