The Influence of Transforming Growth Factor-β1 Gene Polymorphisms on the Severity of Gingival Overgrowth Associated With Concomitant Use of Cyclosporin A and a Calcium Channel Blocker
| Autor: | Derek Middleton, Gerard J. Linden, P.A. Dyer, Simone E. Haworth, P. S. Hull, J. J. Marley, Peter T. McNamee, Kay V. Poulton, A. Peter Maxwell, Colin D. Short, Jacqueline James, Christopher Irwin |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Genotype Proline Arginine medicine.drug_class Calcium channel blocker Biology Transforming Growth Factor beta1 Leucine Transforming Growth Factor beta Cyclosporin a Internal medicine Confidence Intervals Odds Ratio medicine Humans Allele Codon Alleles Analysis of Variance Chi-Square Distribution Polymorphism Genetic Gingival Overgrowth Homozygote Age Factors Heterozygote advantage DNA Transforming growth factor beta Calcium Channel Blockers Kidney Transplantation Logistic Models Endocrinology Gene Expression Regulation Cyclosporine biology.protein Periodontics Female Immunosuppressive Agents Transforming growth factor |
| Zdroj: | Journal of Periodontology. 72:808-814 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.2001.72.6.808 |
| Popis: | The purpose of this study was to determine whether the prevalence and severity of gingival overgrowth in renal transplant recipients concomitantly treated with cyclosporin and a calcium channel blocker was associated with functional polymorphisms within the signal sequence of the transforming growth factor-(TGF)beta1 gene.The extent and severity of gingival overgrowth for 164 renal transplant recipients immunosuppressed with cyclosporin A and concomitantly taking a calcium channel blocker since transplant were entered into the study (86 in Manchester, 78 in Belfast). Two biallelic polymorphisms of the TGF-beta1 gene were studied at position +869, codon 10 (leucine to proline substitution), and position +915, codon 25 (arginine to proline substitution).Subjects who were homozygous for proline at codon 10 had significantly higher overgrowth scores than those who were heterozygous (P= 0.03) or homozygous for leucine (P= 0.01). Subjects who were heterozygous (arginine/proline) at codon 25 had a significantly higher (P= 0.04) gingival overgrowth score than those who were homozygous for arginine. Logistic regression analysis indicated that for codon 25 independent predictors of severe gingival overgrowth were the heterozygous arginine/proline genotype (P= 0.009) and whether the individual was young (P= 0.05).Polymorphisms in the TGF-beta1 gene influence the expression of gingival overgrowth in renal transplant recipients concomitantly treated with cyclosporin and a calcium channel blocker. The polymorphism in the TGF-beta1 gene at codon 25 represented an independent genetic determinant of severe gingival overgrowth in the susceptible subjects studied. |
| Databáze: | OpenAIRE |
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