Erythrocyte Cu/Zn Superoxide Dismutase Activity in Preterm Infants with and without Bronchopulmonary Dysplasia
| Autor: | Yi-Hung Chou, Ming-Chou Chiang, Ren-Huei Fu, Chiao-Ching Chiang, Pen-Hong Yang, Yu-Hsueh Cho |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Gestational Age Infant Premature Diseases Blood cell Superoxide dismutase Internal medicine Zn superoxide dismutase medicine Birth Weight Humans Blood Transfusion Prospective Studies Bronchopulmonary Dysplasia chemistry.chemical_classification biology Superoxide Dismutase business.industry Infant Newborn medicine.disease Cu-Zn superoxide dismutase activity Red blood cell Enzyme medicine.anatomical_structure Endocrinology Bronchopulmonary dysplasia chemistry Pediatrics Perinatology and Child Health Immunology biology.protein Pulmonary Ventilation business Infant Premature Developmental Biology |
| Zdroj: | Neonatology. 88:35-41 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Background: Erythrocyte Cu/Zn superoxide dismutase is believed to play a major role as a first-line antioxidant defense. Studies have reported varying results from measures of superoxide dismutase activity in cord blood samples from neonates. Objective: The study goal was to assess enzyme activity for preterm infants representing a range of gestational ages during the 1st week of life. Clinical data were obtained and correlations with superoxide dismutase activity were examined. Methods: We collected blood samples from umbilical arterial lines or the radial artery of 44 preterm infants (gestational age range 25–30 weeks) on days 1, 3, and 6 after delivery and evaluated erythrocyte Cu/Zn superoxide dismutase activity. Results: There was no correlation between enzyme activity and gestational age or birth weight. Superoxide dismutase activity gradually increased in preterm infants with bronchopulmonary dysplasia on days 3 and 6, with levels significantly higher than those of preterm infants without bronchopulmonary dysplasia on day 6. We found that packed red cell transfusion did not affect erythrocyte superoxide dismutase activity in either group. However, higher cumulative oxygen administration was noted in preterm infants with bronchopulmonary dysplasia. Conclusion: Higher cumulative oxygen administration may be one factor that upregulates the activity of erythrocyte superoxide dismutase. |
| Databáze: | OpenAIRE |
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