Prenatal exposure to selected phthalates and placental DNA methylation in the French EDEN cohort
| Autor: | Jedynak, Paulina, Lepeule, Johanna, Philippat, Claire |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Environmental Health Life Sciences
FOS: Computer and information sciences phthalates DNA methylation placenta Bioinformatics Epidemiology Pharmacology Toxicology and Environmental Health Life Sciences prenatal exposure Other Pharmacology Toxicology and Environmental Health Mother-child cohort Maternal and Child Health Medicine and Health Sciences Epigenetics Public Health EDEN Mother-child cohort Environmental Health Endocrine disruptors |
| DOI: | 10.17605/osf.io/dtcr6 |
| Popis: | The aim of the study is to investigate if there is an association between maternal urine concentrations of phthalates and average levels of DNA methylation measured in placenta after birth. The study was performed on 202 pregnant women from the EDEN mother-child cohort enrolled before 24 weeks of gestation in Nancy and Poitiers university hospitals, France, between 2003 and 2006. DNA methylation was measured in the placental tissue samples using the Illumina's Infinium HumanMethylation450 BeadChip assay, representing over 485,000 individual CpG sites. |
| Databáze: | OpenAIRE |
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