Physical and chemical profiles of nanoparticles for lymphatic targeting
| Autor: | Bei Cheng, Xiyu Ke, José Luís Guedes dos Santos, Hai-Quan Mao, May Tun Saung, Haoyu Tang, Gregory P. Howard |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Surface Properties
medicine.medical_treatment Pharmaceutical Science Nanoparticle 02 engineering and technology 03 medical and health sciences Drug Delivery Systems Immune system medicine Animals Humans Particle Size Lymph node 030304 developmental biology Targeting ligands 0303 health sciences Chemistry Lymphatic targeting Dendritic Cells Immunotherapy 021001 nanoscience & nanotechnology Cell biology medicine.anatomical_structure Nanoparticles Lymph Nodes 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Advanced Drug Delivery Reviews. :72-93 |
| ISSN: | 0169-409X |
| Popis: | Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy. |
| Databáze: | OpenAIRE |
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