Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS
| Autor: | Subhabrata Moitra, Anne-Elie Carsin, Michael J Abramson, Simone Accordini, Andre F S Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A Gullón, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gómez Real, Debbie Jarvis, Bénédicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich |
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| Přispěvatelé: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
NATIONAL-HEALTH Respiratory Medicine and Allergy Asthma Epidemiology NUTRITION EXAMINATION ASSOCIATION SMOKING-CESSATION GENERAL-PRACTITIONERS Asthma WEIGHT-GAIN BODY-MASS INDEX COMMUNITY LUNG-FUNCTION PHYSICAL-ACTIVITY Clinical Epidemiology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Human medicine Lungmedicin och allergi |
| Zdroj: | Thorax Thorax, BMJ Publishing Group, 2022, ⟨10.1136/thoraxjnl-2021-217867⟩ Thorax, 78(2), 128-135. BMJ Publishing Group Thorax 78, 128-135 (2023) |
| ISSN: | 0040-6376 |
| Popis: | IntroductionObesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults.MethodsWe used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m2) individuals at visitt. The relative risk (RR) of obesity att+1associated with asthma attwas estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity.ResultsWe included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II—III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association.ConclusionThis is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids. |
| Databáze: | OpenAIRE |
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