Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas
| Autor: | Scott C. Edmunds, F Di Nicolantonio, Ian A. Cree, David P. Kelsell, John L. Hungerford, Jeremy Hurren |
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| Rok vydání: | 2003 |
| Předmět: |
Proto-Oncogene Proteins B-raf
Uveal Neoplasms Cancer Research Pathology medicine.medical_specialty Skin Neoplasms endocrine system diseases BRAF melanoma cancer mutations oncogene DNA sequence Uveal Neoplasm Biology Gene mutation medicine.disease_cause Polymerase Chain Reaction Exon Tumor Cells Cultured medicine Humans Lung cancer neoplasms DNA Primers Oncogene Proteins Mutation Base Sequence Melanoma High Mobility Group Proteins Molecular and Cellular Pathology Exons Uvea medicine.disease digestive system diseases eye diseases DNA-Binding Proteins medicine.anatomical_structure Oncology Cutaneous melanoma sense organs |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6600919 |
| Popis: | The recent discovery of activating mutations in the BRAF gene in many cutaneous melanomas led us to screen the genomic sequence of BRAF exons 11 and 15 in a series of 48 intraocular (uveal) melanomas, together with control samples from three cutaneous melanomas and the SK-Mel-28 cell line, which has a BRAF mutation. The same mutation was detected in two-thirds of our cutaneous melanoma samples, but was not present in any uveal melanomas. This finding further underlines the distinction between uveal and cutaneous melanomas, and suggests that BRAF inhibitors are unlikely to benefit patients with uveal melanoma. |
| Databáze: | OpenAIRE |
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