Prophylactic vaginal dinoprostone administration six hours prior to copper-T380A intrauterine device insertion in nulliparous women: A randomized controlled trial
| Autor: | Hossam Abdou, Hala A-Wahab, Sherif Sameh Zaki, Amr Hussein, Ahmed Ibrahim, Mohamed Hamed Hussein, Mohamed El Mahy, Mohamed Fikry Yosif Kasem, Rana Abdella, Ahmed El Lithy, Ahmed Taher Masoud, Ahmed Alaa El Din Wali, Amal Hanafy Hussien, Mona Mostafa, Ahmed A. Mageed A. Allah, Ahmed Samy, Hossam H. Soliman |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Visual analogue scale Pain Procedural Placebo Intrauterine device Placebo group Dinoprostone law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Humans Medicine 030212 general & internal medicine Pain Measurement 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology Iud insertion Intrauterine Devices Copper Administration Intravaginal Parity Reproductive Medicine Baseline characteristics Egypt Female business |
| Zdroj: | Contraception. 101:162-166 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/j.contraception.2019.10.012 |
| Popis: | To determine the effectiveness of 3 mg vaginal dinoprostone administered six hours prior to copper intrauterine device (IUD) insertion compared to placebo in increasing ease of insertion and reducing insertion pain among nulliparous women.This was a single-center double-blinded randomized controlled trial (RCT). We randomly divided the two hundred nulliparous women requesting a copper T380A IUD to receive 3 mg vaginal dinoprostone or placebo six hours before IUD insertion. The primary outcome was provider ease of insertion. Patients reported their perceived insertion pain using a 10 cm visual analog scale (VAS). We also reported number of failed IUD insertions.Baseline characteristics were similar between groups. Ease of insertion score was lower in dinoprostone group than placebo group (3.6 ± 2.5 vs. 5.4 ± 2.8; p 0.01) denoting easier insertion for clinicians in dinoprostone group. Mean pain score during copper IUD insertion was lower in dinoprostone group (3.7 ± 2.3 vs. 5.0 ± 2.8; p 0.01). Failed IUD insertion occurred in two cases of dinoprostone group (2%) versus four cases in control group (4%) (p-value; 0.68).Although vaginal dinoprostone administration six hours prior to copper IUD insertion in nulliparous women leads to an easy IUD insertion, we do not routinely advise it as the reduction in IUD insertion pain scores with vaginal dinoprostone lacked clinical significance.In settings where it is feasible to provide dinoprostone vaginally six hours before copper IUD insertion, clinicians will find insertion easier, and nulliparous women may experience somewhat less pain during the procedure. Where waiting six hours is practical, this may prove to be useful. |
| Databáze: | OpenAIRE |
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