Perennisosides I−VII, Acylated Triterpene Saponins with Antihyperlipidemic Activities from the Flowers of Bellis perennis
| Autor: | Eriko Nishida, Yuki Ito, Masayuki Yoshikawa, Seikou Nakamura, Toshio Morikawa, Xuezheng Li, Osamu Muraoka, Hisashi Matsuda |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Stereochemistry Saponin Pharmaceutical Science Mice Inbred Strains Flowers Asteraceae Pharmacognosy Bellis perennis Analytical Chemistry Mice chemistry.chemical_compound Triterpene Drug Discovery Animals Hypolipidemic Agents Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure biology Traditional medicine Triglyceride Organic Chemistry Glycoside Biological activity Lipase Saponins biology.organism_classification Triterpenes Terpenoid Complementary and alternative medicine chemistry Molecular Medicine |
| Zdroj: | Journal of Natural Products. 71:828-835 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np8000333 |
| Popis: | The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III (3), IV (4), V (5), VI (6), and VII (7), were isolated together with four known saponins, bellidioside A (8), asterbatanoside D (9), bernardioside B 2 (10), and bellissaponin BS6 (11). The stereostructures of 1- 7 were elucidated on the basis of chemical and spectroscopic evidence. Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25-50 mg/kg, po. |
| Databáze: | OpenAIRE |
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