The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future
| Autor: | Emily E Dando, Maria K. Hordinsky, Angela Wipf, Nicholas Charles Boysen, Neil S. Sadick, Ronda S. Farah |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Triamcinolone acetonide Alopecia Areata Administration Topical Administration Oral Dermatology Skin Diseases 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Transdermal Evidence-Based Medicine integumentary system business.industry Alopecia Alopecia areata medicine.disease Topical medication Clinical trial Hair loss chemistry 030220 oncology & carcinogenesis Drug delivery Finasteride Female Surgery Dermatologic Agents Laser Therapy business medicine.drug |
| Zdroj: | Journal of Cosmetic and Laser Therapy. 21:247-254 |
| ISSN: | 1476-4180 1476-4172 |
| Popis: | Introduction: Fractional lasers and microneedling devices are increasingly used with topical drugs to treat various conditions, including alopecia, as they grant access to dermal structures such as hair follicles and cutaneous vasculature. Objective: To perform a comprehensive review on transcutaneous drug delivery for the management of alopecia. Methods: PubMed, Embase, and Ovid Medline databases were searched using terms including: alopecia, microneedling, lasers, androgenetic alopecia (AGA), alopecia areata (AA), drug delivery. Articles were examined for inclusion criteria: diagnosis of alopecia regardless of type, use of fractional laser or microneedling devices, and subsequent administration of topical medication. Results: 8 studies, 6 prospective clinical trials and 2 case series, examining either AA or AGA were identified. For AA, five studies examined microneedling together with topical triamcinolone in three of these, while two studies used photodynamic therapy. Regarding AGA, two studies used topical minoxidil plus microneedling, and one examined topical finasteride with fractional erbium glass laser. Improvement was seen in 6 of the 8 studies. Discussion: Transcutaneous drug delivery via fractional laser and microneedling is a promising modality with preliminary evidence for increased hair regrowth over topical therapy alone. Further studies are needed to elucidate treatment parameters and appropriate device selection for drug delivery. |
| Databáze: | OpenAIRE |
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