High expression of Anxa2 and Stat3 promote progression of hepatocellular carcinoma and predict poor prognosis
| Autor: | Danhua Zhou, Xudong Chen, Rong-Rong Wang, Zijuan Zhang, Xuening Zhang, Cuihua Lu, Chenzhou Xu, Wei-Rong Huang, Mingbing Xiao, Jinxia Liu, Lishuai Qu, Lei Tang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult Male STAT3 Transcription Factor Poor prognosis medicine.medical_specialty Carcinoma Hepatocellular Kaplan-Meier Estimate Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Western blot Internal medicine medicine Carcinoma Biomarkers Tumor Humans STAT3 Pathological Annexin A2 Aged medicine.diagnostic_test biology business.industry Incidence (epidemiology) Liver Neoplasms Cell Biology Middle Aged medicine.disease Prognosis digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma biology.protein Disease Progression Immunohistochemistry Female Neoplasm Recurrence Local business |
| Zdroj: | Pathology, research and practice. 215(6) |
| ISSN: | 1618-0631 |
| Popis: | To elucidate whether the interaction between Anxa2 and Stat3 could promote the progression of hepatocellular carcinoma (HCC) and that high co-expression of Anxa2 and Stat3 could predict poor prognosis in HCC patients.We investigated Anxa2 and Stat3 expression using Western blot analysis in 4 HCC and adjacent nontumor tissues and using immunohistochemistry in 100 patients' paraffin sections. Then we assessed the expression of Stat3, Anxa2 and co-expression of Stat3 and Anxa2 with relevant clinical pathological parameters and their prognostic value in HCC patients. The recurrence and overall survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models.The incidence of high Stat3 expression in HCC tissues (35%) was significantly higher than that in non-HCC tissues (8%) (P 0.001). The same result was observed in Anxa2 (P 0.001). Also, the overexpression of Stat3 or Anxa2 showed a significant relationship with the recurrence of the 100 HCC patients (P = 0.012; P = 0.003). Additionally, tumor size3 cm in diameter, multiple tumor number, and the presence of microvascular tumor thrombus were also significantly associated with recurrence in 100 patients. Then, all enrolled patients were divided into four groups according to IHC score of Stat3 and Anxa2, and the results indicated a significant difference in recurrence time between the subgroups (P 0.001). What's more, co-highexpression of Stat3 and Anxa2 was related to the presence of microvascular tumor thrombus (P = 0.003) and poor tumor differentiation (P 0.001), but not relevant with other clinical features (All P 0.05).The expression of Stat3, Anxa2, or co-high-expression of the two proteins was associated with HCC recurrence and survival. |
| Databáze: | OpenAIRE |
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