Solvent suppression of the decomposition of phenobarbital during on-column methylation with trimethylanilinium hydroxide
| Autor: | Irving Sunshine, Raymond C. Kelly, James C. Valentour |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Chromatography
Gas Chemical Phenomena medicine.drug_class Biochemistry Methylation Analytical Chemistry chemistry.chemical_compound medicine Humans Chemical decomposition Chromatography Aniline Compounds Chemistry Organic Chemistry Injection port General Medicine Decomposition Barbiturate Phenobarbital Hydroxide Indicators and Reagents Gas chromatography Primidone medicine.drug |
| Zdroj: | Journal of chromatography. 138(2) |
| Popis: | Gas-liquid chromatographic (GLC) analysis of phenobarbital by on-column methylation with trimethylanilinium hydroxide gives rise to a major decomposition product, N-methyl-2-phenylbutyramide, in addition to the methylated barbiturate, N,N′-dimethylphenobarbital. This reaction occurs nearly exclusively in the solution phase in the injection port of the gas chromatograph. A mechanism for the decomposition reaction consistent with the available information is presented. This decomposition is shown to be inhibited by certain solvents and this effect forms the basis of a new analytical technique for the simultaneous GLC analysis of phenobarbital, primidone, and diphenylhydantoin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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