Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants
| Autor: | Beatriz Fernandez-Fernandez, Pablo Cannata-Ortiz, Alberto Ortiz, Carolina Gracia, Miguel Ángel Martínez-González, Catalina Martin-Cleary, Antonio Barat, Luis Requena, Gabriela Rossello, Youssef Aouad |
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| Přispěvatelé: | UAM. Departamento de Anatomía Patológica, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) |
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Filler (packaging) Pathology Histology Polymethylmetacrylate Medicina Biopsy Injections Subcutaneous Embolism 030232 urology & nephrology Fluorescent Antibody Technique Biocompatible Materials Case Report Cosmetic Techniques Post-infectious glomerulonephritis Dermal Fillers Esthetic filler implants Microsphere Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences Subcutaneous injection Nephritic syndrome Glomerulonephritis 0302 clinical medicine Foreign-Body Migration Predictive Value of Tests Streptococcal Infections Humans Polymethyl Methacrylate Medicine C3 glomerulopathy medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Microspheres Surgery Acute Disease Female business |
| Zdroj: | Biblos-e Archivo. Repositorio Institucional de la UAM instname Diagnostic Pathology |
| ISSN: | 1746-1596 |
| DOI: | 10.1186/s13000-016-0453-y |
| Popis: | Background: The systemic consequences of esthetic filler injections are poorly understood. Case presentation: We report a patient with a past history of subcutaneous injection of aesthetic filler material in the lower legs, who presented with post-infectious glomerulonephritis following necrotic leg ulcers at the injection site. Kidney biopsy revealed the presence of translucent, non-birefringent microspherical bodies compatible with polymethylmetacrylate (PMMA) microspheres in some capillary lumens. This had not previously been described. PMMA is a biphasic aesthetical filler composed of polymethylmetacrylate microspheres suspended in a biodegradable bovine collagen carrier. The solid phase (PMMA microspheres) persists in tissues for years. Although PMMA was thought to not disseminate systemically, tissue necrosis may have favored systemic dissemination of the microspheres, although entry in the circulation and microembolization at the time of administration cannot be ruled out. Conclusions: In conclusion, aesthetic filler implants may cause microembolization into small vessels. Recognition of the characteristic morphology may expedite diagnosis and avoid unnecessary further testing. AO and CMC were supported by ISCIII and FEDER funds PI13/00047, REDinREN RD012/0021, Comunidad de Madrid CIFRA S2010/BMD-2378 and Programa Intensificación Actividad Investigadora. BFF by ISCIII Joan Rodes. |
| Databáze: | OpenAIRE |
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