Synthesis of the C12−C19 Fragment of (+)-Peloruside A through a Diastereomer-Discriminating RCM Reaction
| Autor: | Mikhail S. Ermolenko, Emmanuel Roulland |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Molecular Structure
Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Diastereomer Antineoplastic Agents Stereoisomerism Alcohol Bridged Bicyclo Compounds Heterocyclic Biochemistry Combinatorial chemistry Porifera Lactones chemistry.chemical_compound Fragment (logic) Animals Epoxy Compounds Peloruside A Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 7:2225-2228 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol050588k |
| Popis: | [reaction: see text]. A short and efficient asymmetric synthesis of the C12-C19 fragment of the cytotoxic macrolide (+)-peloruside A has been achieved via a highly diastereomer-discriminating RCM of alpha-branched but-3-enoate ester of a methallylic alcohol derived from hydrolytically resolved (S)-(-)-propylene oxide. |
| Databáze: | OpenAIRE |
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