Altered brain protein kinase C in depression: a post-mortem study
| Autor: | Roger W. Horton, Moyra A. Coull, Sandra Lowther, Cornelius Katona |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Frontal cortex Prefrontal Cortex Hippocampus chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Binding site Phorbol 12 13-Dibutyrate Protein Kinase C Biological Psychiatry Protein kinase C Depression (differential diagnoses) Pharmacology Binding Sites Depression Antidepressive Agents Pathophysiology Suicide Psychiatry and Mental health Endocrinology Neurology chemistry Postmortem Changes Anesthesia Phorbol Antidepressant Female Neurology (clinical) |
| Zdroj: | European Neuropsychopharmacology. 10:283-288 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(00)00084-5 |
| Popis: | [(3)H]Phorbol 12,13-dibutyrate (PDBu) binding was measured in soluble and particulate fractions of frontal cortex and hippocampus from suicides, with a firm retrospective diagnosis of depression, and individually matched controls. Suicides were divided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. In frontal cortex, there was a significantly higher number (by 75%) of [(3)H]PDBu binding sites in the soluble fraction in antidepressant-free suicides compared to controls; significant differences were also seen in the proportion of sites in the soluble and particulate fractions. Higher numbers of [(3)H]PDBu binding sites in the particulate fraction of hippocampus in antidepressant-free suicides was restricted to those who died by violent means. No significant differences in the number of [(3)H]PDBu binding sites were found in antidepressant-treated suicides compared to controls. This study provides evidence for the involvement of protein kinase C in the pathophysiology of depression. |
| Databáze: | OpenAIRE |
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