Is the nuclear factor kappa-b (NF-κB) pathway and inflammatory status associated with colorectal cancer?
| Autor: | Dogan Uncu, Büşra Atabilen, Gamze Akbulut, Merve Bacanli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Overweight Gastroenterology Nuclear factor kappa b Body Mass Index chemistry.chemical_compound Internal medicine Genetic predisposition medicine Humans Aged business.industry Significant difference NF-kappa B NF-κB Middle Aged medicine.disease Diet chemistry Etiology medicine.symptom business Colorectal Neoplasms Body mass index |
| Zdroj: | Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. 28(1) |
| ISSN: | 1998-4049 |
| Popis: | © 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background: Although genetic predisposition has a role in the etiology of colorectal cancer, there are many other factors that affect its development. In this study, it was aimed to evaluate the NF-κB pathway, inflammatory status and dietary antioxidant capacity in individuals with colorectal cancer. Methods: The study was carried out with 40 male subjects diagnosed with colorectal cancer aged between 39-65, years and a control group of the same number of healthy men. Subjects in the case and control groups were subdivided according to body mass index (BMI), as normal (BMI 20-24.9 kg/m 2) or overweight/obese (BMI ≥25 kg/m 2). Results: At the end of the study, NF-κB and interleukin-22 levels were higher in the case group, but no significant difference was found between the groups. Interleukin-23 and 8-Hydroxy-2-deoxyguanosine levels in the case group classified as overweight/obese according to BMI were significantly higher than in the control group (P = 0.001 and P < 0.001, respectively). Considering diet antioxidant capacity, it was higher in individuals in the control group than in the case group. However, there was no significant difference between the groups. Conclusion: Inflammatory status and reduced dietary antioxidant capacity are risk factors in the development of colorectal cancer. |
| Databáze: | OpenAIRE |
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