Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder

Autor:	Mari Hämäläinen, Eeva Moilanen, Annamari Sorri, Kai Lehtimäki, Kati Tuohimaa, Kaija Järventausta, Esa Leinonen, Olli Kampman, Minna Björkqvist
Přispěvatelé:	Tampere University, Department of Mood Disorders, Clinical Medicine, Department of Psychotic Disorders, Department of Neurosciences and Rehabilitation, Department of Child Psychiatry, BioMediTech, Tays Research Services
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Oncology Vascular Endothelial Growth Factor A medicine.medical_specialty medicine.medical_treatment Neurosciences. Biological psychiatry. Neuropsychiatry Behavioral neuroscience behavioral disciplines and activities 3124 Neurology and psychiatry Behavioral Neuroscience chemistry.chemical_compound Electroconvulsive therapy Rating scale Internal medicine mental disorders Medicine Humans In patient Electroconvulsive Therapy Depression (differential diagnoses) Original Research Depressive Disorder Major major depressive disorder vascular endothelial growth factor business.industry Vascular Endothelial Growth Factors medicine.disease Vascular endothelial growth factor Treatment Outcome chemistry Etiology Major depressive disorder business RC321-571
Zdroj:	Brain and Behavior Brain and Behavior, Vol 11, Iss 8, Pp n/a-n/a (2021)
ISSN:	2162-3279
Popis:	Objectives Vascular endothelial growth factor (VEGF) has been related to the etiology of major depressive disorder (MDD). The findings involving the effects of electroconvulsive therapy (ECT) on the VEGF levels have been conflicting. The aim was to examine the possible changes in the VEGF levels and their associations with clinical outcome in patients with MDD during ECT. Methods The study comprised 30 patients suffering from MDD. Their plasma VEGF levels were measured at baseline and 2 and 4 hr after the first, fifth, and last ECT session. The severity of depression was quantified by the Montgomery‐Asberg Depression Rating Scale (MADRS). Results The VEGF levels increased between the 2‐hr and 4‐hr measurements during the first (p = .003) and the fifth (p = .017) sessions. The baseline VEGF levels between individual ECT sessions remained unchanged during the ECT series. No correlations were found between the increased VEGF levels and the clinical outcome. Conclusions Electroconvulsive therapy increased the VEGF levels repeatedly at the same time point in two different ECT sessions. These increases had no association with the response to ECT. Consequently, VEGF may act as a mediator in the mechanism of action of ECT. Plasma VEGF levels of patients suffering from MDD were measured in different time points during ECT series. ECT increased the VEGF levels repeatedly at the same time point in two different ECT sessions but these increases had no association with the response to ECT. Consequently, VEGF may act as a mediator in the mechanism of action of ECT.
Databáze:	OpenAIRE
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