Increased hepcidin levels and non-alcoholic fatty liver disease in obese prepubertal children: a further piece to the complex puzzle of metabolic derangements
Autor: | Nella Polidori, Raffaella Basilico, Cosimo Giannini, Francesco Chiarelli, Angelika Mohn, Maria Alessandra Saltarelli |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Pediatric Obesity Adolescent Endocrinology Diabetes and Metabolism Iron medicine.disease_cause Endocrinology Insulin resistance Hepcidins Hepcidin Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease medicine Humans Child biology medicine.diagnostic_test business.industry Fatty liver Puberty nutritional and metabolic diseases medicine.disease Obesity Logistic Models Child Preschool Pediatrics Perinatology and Child Health biology.protein Female Liver function Insulin Resistance business Lipid profile Oxidative stress |
Zdroj: | Journal of pediatric endocrinologymetabolism : JPEMReferences. 35(1) |
ISSN: | 2191-0251 |
Popis: | Introduction Several studies on obese youths and adults have reported increased hepcidin levels, which seems to be related to metabolic and iron metabolism alterations. The complete mechanisms involved in hepcidin increase remain to be elucidated, and particularly its role in the development of other known complications such as Nonalcoholic Fatty Liver Disease (NAFLD). NAFLD in prepubertal children might be of special interest in understanding the underlying mechanisms. Methods Anthropometric measurements, liver ultrasonography, lipid profile, liver function, oxidative stress, inflammatory state, and iron metabolism were studied in 42 obese prepubertal children and 33 healthy controls. We, therefore, evaluated the presence of possible correlations between Hepcidin and the other metabolic variables, and the possible association between NAFLD and iron metabolism. Results Hepcidin levels were significantly increased in the obese prepubertal children (p=0.001) with significant differences between obese children with and without NAFLD (p=0.01). Blood iron was lower in obese children (p=0.009). In the obese group, a negative correlation between hepcidin and both blood iron levels (p=0.01) and LagPHASE (p=0.02) was found. In addition, a positive association between hepcidin and NAFLD (p=0.03) was detected. Conclusions We suggest that an increase in hepcidin levels may represent an early step in iron metabolism derangements and metabolic alterations, including NAFLD, in prepubertal obese children. |
Databáze: | OpenAIRE |
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