Age-related treatment patterns for stage I NSCLC in three European countries
| Autor: | Aamir Khakwani, Suresh Senan, Ȧslaug Helland, Trond Eirik Strand, Ronald A.M. Damhuis, Susan Harden |
|---|---|
| Přispěvatelé: | Radiation Oncology, CCA - Cancer Treatment and quality of life |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Octogenarians Stereotactic body radiation therapy medicine.medical_treatment Population Radiosurgery 03 medical and health sciences 0302 clinical medicine Internal medicine Age related Carcinoma Non-Small-Cell Lung Medicine Humans In patient 030212 general & internal medicine education Neoplasm Staging Aged 80 and over education.field_of_study business.industry medicine.disease Comorbidity Small Cell Lung Carcinoma Radiation therapy Treatment utilization Oncology Cardiothoracic surgery 030220 oncology & carcinogenesis Geriatrics and Gerontology business |
| Zdroj: | Journal of Geriatric Oncology, 12(8), 1214-1219. Elsevier Ltd Damhuis, R A M, Senan, S, Khakwani, A, Harden, S, Helland, Ȧ & Strand, T E 2021, ' Age-related treatment patterns for stage I NSCLC in three European countries ', Journal of Geriatric Oncology, vol. 12, no. 8, pp. 1214-1219 . https://doi.org/10.1016/j.jgo.2021.05.005 |
| ISSN: | 1879-4076 1879-4068 |
| Popis: | Introduction Surgery is the preferred treatment for patients with early-stage non-small cell lung cancer (NSCLC) while stereotactic body radiation therapy (SBRT) may be applied in patients with major comorbidity or high age. We evaluated the association between age and treatment utilization for early-stage NSCLC in patients diagnosed in 2015–2016 in three European countries. Patients and methods Information was retrieved from population-based registries in England, Norway and the Netherlands. Treatment patterns and two-year overall survival rates for 105,124 patients with clinical stage I were analysed by age-group. Results Surgical resection rates were higher in Norway (55%) and England (53%) than in the Netherlands (47%), and decreased with increasing age. SBRT use was highest in the Netherlands (41%), followed by Norway (29%) and England (12%). In the Netherlands, SBRT was the prevailing treatment in patients aged 70 years or older. In octogenarians, the proportion not receiving curative intent treatment was 53% in England, versus 35% in Norway and 22% in the Netherlands. Two-year survival rates were better for surgery than for SBRT and slightly better in Norway. Conclusion In patients aged 70 years or older, the proportion not receiving any curative treatment remains substantial, and differs significantly between countries. Measures to address these disparities are needed. |
| Databáze: | OpenAIRE |
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