A multicenter retrospective analysis on therapeutic plasma exchange in immune thrombocytopenic purpura
| Autor: | Bülent Eser, Turgay Ulas, Serdal Korkmaz, Ali Dogan, Asli Kum, Ahmet Sarici, Fevzi Altuntaş, Omer Ekinci, Serhat Sayin, Abdulkadir Basturk, Irfan Kuku, Ilhami Berber, Mehmet Ali Erkurt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty medicine.medical_treatment Splenectomy Gastroenterology Pathogenesis Young Adult Immune system Refractory immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans Aged Retrospective Studies Autoimmune disease Purpura Thrombocytopenic Idiopathic Plasma Exchange biology business.industry Immunoglobulins Intravenous Hematology Middle Aged medicine.disease Thrombocytopenia Thrombocytopenic purpura Immunoglobulin M Thrombopoietin Immunoglobulin G biology.protein Female Rituximab Antibody business Receptors Thrombopoietin medicine.drug |
| Zdroj: | Transfusion and Apheresis Science. 60:103246 |
| ISSN: | 1473-0502 |
| DOI: | 10.1016/j.transci.2021.103246 |
| Popis: | Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia and skin and mucosal bleeding. In patients with an indication for treatment, corticosteroids, intravenous immunoglobulin (IVIg) and anti-D are recommended as the first line, while splenectomy, thrombopoietin receptor agonists or rituximab are recommended second line options. Approximately 10 % of adult patients with ITP fall into the chronic refractory ITP group. Therapeutic plasma exchange (TPE) has generally been tested in patients with refractory ITP, who have failed to respond to conventional treatments, in case of bleeding or prior to surgical interventions. It has been stated that elimination of the antibodies that are held responsible in the pathogenesis of the disease has an effective role in the treatment. In this article, we present the results of 17 patients, who underwent TPE for refractory ITP, together with the literature data. |
| Databáze: | OpenAIRE |
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