The emerging role of transport systems in liver function tests
| Autor: | Thomas M. van Gulik, Wilmar de Graaf, Michal Heger, Gustav Paumgartner, Bruno Stieger |
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| Přispěvatelé: | University of Zurich, Stieger, B, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Surgery |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Organic Anion Transporters 610 Medicine & health Disease Bioinformatics Severity of Illness Index chemistry.chemical_compound Liver disease Liver Function Tests Animals Hepatic Insufficiency Humans Protein Isoforms Medicine Pharmacology medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Transplantation 3004 Pharmacology medicine.anatomical_structure Breath Tests Liver chemistry 10199 Clinic for Clinical Pharmacology and Toxicology 10076 Center for Integrative Human Physiology Hepatocyte 570 Life sciences biology ATP-Binding Cassette Transporters Indicators and Reagents Liver function business Liver function tests Indocyanine green Biomarkers |
| Zdroj: | European journal of pharmacology, 675(1-3), 1-5. Elsevier |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2011.11.048 |
| Popis: | Liver function tests are of critical importance for the management of patients with severe or terminal liver disease. They are also used as prognostic tools for planning liver resections. In recent years many transport systems have been identified that also transport substances employed in liver function tests. Such substances include endogenous bilirubin or exogenously administered indocyanine green, agents for magnetic resonance imaging, agents for single photon emission computed tomography or agents for breath tests. The increasing functional and molecular information on the respective transport systems should improve the management and as a result the outcome of patients scheduled for liver surgery or transplantation. To achieve the latter goal, clinical studies that assess individual patients' liver function over the course of their disease with liver function tests are needed to firmly establish and validate recently introduced and novel liver function markers. (C) 2011 Elsevier B.V. All rights reserved |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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