Optimal Management of the Critically Ill: Anaesthesia, Monitoring, Data Capture, and Point-of-Care Technological Practices in Ovine Models of Critical Care
| Autor: | Charles McDonald, Gabriela Simonova, Judith Bellpart, Rylan A Hayes, Kimble R. Dunster, David Platts, Marc O. Maybauer, Kiran Shekar, Samuel R. Foley, Sara Diab, Michael H Toon, Yoke Lin Fung, Ryan P. Watts, John-Paul Tung, John F. Fraser, Michelle S Chew, Saul Chemonges, Shaun D. Gregory, Daniel Timms |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Critical Care Critical Illness Point-of-Care Systems Psychological intervention Information Storage and Retrieval lcsh:Medicine Review Article General Biochemistry Genetics and Molecular Biology medicine Animals Humans Anesthesia Intensive care medicine Point of care Monitoring Physiologic Sheep General Immunology and Microbiology business.industry Critically ill lcsh:R General Medicine medicine.disease Optimal management Disease Models Animal Skill mix Monitoring data Critical illness business Transfusion-related acute lung injury |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Animal models of critical illness are vital in biomedical research. They provide possibilities for the investigation of pathophysiological processes that may not otherwise be possible in humans. In order to be clinically applicable, the model should simulate the critical care situation realistically, including anaesthesia, monitoring, sampling, utilising appropriate personnel skill mix, and therapeutic interventions. There are limited data documenting the constitution of ideal technologically advanced large animal critical care practices and all the processes of the animal model. In this paper, we describe the procedure of animal preparation, anaesthesia induction and maintenance, physiologic monitoring, data capture, point-of-care technology, and animal aftercare that has been successfully used to study several novel ovine models of critical illness. The relevant investigations are on respiratory failure due to smoke inhalation, transfusion related acute lung injury, endotoxin-induced proteogenomic alterations, haemorrhagic shock, septic shock, brain death, cerebral microcirculation, and artificial heart studies. We have demonstrated the functionality of monitoring practices during anaesthesia required to provide a platform for undertaking systematic investigations in complex ovine models of critical illness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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