Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis
| Autor: | Pedro Martínez-Ayala, Alejandro Quiñonez-Flores, Luz Alicia González-Hernández, Vida Verónica Ruíz-Herrera, Sergio Zúñiga-Quiñones, Guillermo Adrián Alanis-Sánchez, Rodolfo Ismael Cabrera-Silva, Fernando Amador-Lara, Karina Sánchez-Reyes, Monserrat Álvarez-Zavala, Juan Carlos Vázquez-Limón, Juan Pablo Sánchez-Navarro, Jaime Federico Andrade-Villanueva |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of STD & AIDS. 33:330-336 |
| ISSN: | 1758-1052 0956-4624 |
| Popis: | Background The diagnosis of neurosyphilis is a challenge, and the criteria for deciding when to perform a lumbar puncture are still controversial, especially in people living with HIV with a late latent syphilis diagnosis. Methods Retrospective analysis of demographic, clinical, and laboratory data of people with HIV and documented late latent syphilis or syphilis of unknown duration with a cerebrospinal fluid VDRL test. Results 122 patients were evaluated, of whom 52 had the diagnosis of neurosyphilis. Patients with and without neurosyphilis presented a similar viral load and lymphocyte CD4+ T-cell count. Neurological symptoms (OR 6.4, 95% CI 2.1–22.4; p < 0.01), serum VDRL titers of 1:32 ( pConclusion Neurological symptoms, particularly headache, were predictors of neurosyphilis in people with HIV irrespective of their viral load and lymphocyte CD4+ T-cell count in late latent syphilis. A serum VDRL ≥1:32 increased the risk of neurosyphilis in patients with or without any symptoms. |
| Databáze: | OpenAIRE |
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