Pup circadian rhythm entrainment—effect of maternal ganglionectomy or pinealectomy
| Autor: | Agata R. Carpentieri, N. T. Vermouth, S. L. Bellavia, A. M. Vaqué, Ana Fabiola Macchione |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
endocrine system medicine.medical_specialty medicine.medical_treatment Drinking Behavior Pinealectomy Experimental and Cognitive Psychology Motor Activity Biology Pineal Gland Melatonin Behavioral Neuroscience Pineal gland Pregnancy Internal medicine medicine Animals Circadian rhythm Ganglionectomy Rats Wistar Analysis of Variance Behavior Animal medicine.disease Circadian Rhythm Rats Endocrinology medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects Gestation Female Endocrine gland medicine.drug |
| Zdroj: | Physiology & Behavior. 89:342-349 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2006.06.018 |
| Popis: | In rodents, during late embryonic and early neonatal development, circadian rhythms develop in synchrony with those of their mothers, which in turn are synchronized with the environmental photoperiod. This paper examines the effect of maternal ganglionectomy (pineal gland sympathetic denervation) or extirpation of the pineal gland on pups' drinking rhythms, a behavior that is continuously monitored in individual animals starting after weaning and studied up to 3 weeks later. Maternal ganglionectomy or pinealectomy performed on the 7th day of gestation significantly disrupts rat pups' drinking behavior, within and among litters. In both treatments, circadian rhythm characteristics of the free-running period (tau), phase, amplitude and alpha were significantly altered compared to those of the control pups born from sham-operated mothers. With the exception of the alpha component, both maternal treatments have similar effects. When melatonin was given to the mothers instead of the endogenous pineal secretory activity for 5 days during the late period of gestation, this treatment reversed the effects of maternal ganglionectomy and pinealectomy. These observations, together with previous studies of our group, indicate that the maternal superior cervical ganglia and pineal gland are necessary components of the mechanism for maternal synchronization, and that maternal melatonin may, directly or indirectly, affect the performance of the pups' central oscillator during early pup rat development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect