Duration dependent effect of chronic stress on primary and secondary lymphoid organs and their reversibility in rats
| Autor: | H N Yajurvedi, H N Sarjan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Restraint Physical 0301 basic medicine White pulp Axillary lymph nodes Lymphoid Tissue Lymphocyte Immunology Physiology Apoptosis Spleen Thymus Gland 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stress Physiological Corticosterone medicine Animals Humans Immunology and Allergy Chronic stress Involution (medicine) Lymphocytes Cells Cultured Thymocytes business.industry Rats Inbred Strains Hematology Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Lymphatic system chemistry Chronic Disease Lymph Nodes business 030215 immunology |
| Zdroj: | Immunobiology. 224:133-141 |
| ISSN: | 0171-2985 |
| Popis: | The present study was undertaken to investigate whether or not chronic stress effect and its reversibility on lymphoid organs is duration dependent. Male rats were exposed to restraint (1 h) followed by a gap of 4 h to forced swimming exercise (15 min) daily for 2, 4 and 8 weeks. After each exposure period, rats were allowed to recover for 6 weeks. Stress exposure resulted in duration dependent decreases in weight of thymus and axillary lymph nodes, lymphocyte counts of spleen, thymus and axillary lymph nodes and number of islets of white pulp of spleen and increases in apoptotic index of splenocytes, thymocytes and lymphocytes of axillary lymph nodes. All the parameters of lymphoid organs studied showed significant alterations in 2 weeks of stress exposure indicated their sensitivity to stress effects in short term exposure and thymus was the most sensitive organ among all. The alterations in all the parameters of spleen and majority of parameters of thymus and axillary lymph nodes returned to control level in recovery group rats of 2 and 4 weeks exposure but not in that of 8 weeks exposure. The present study for the first time reveal that severity of stress effects on lymphoid organs increases with increasing duration of exposure and shorter the exposure period faster the recovery. In addition, an in vitro study showed that corticosterone caused apoptosis of thymocytes, splenocytes and lymphocytes of axillary lymph nodes in dose dependent manner. Thus corticosterone induced death of cells of lymphoid organs under stress is the major cause of involution of lymphoid organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect