Synthesis, in vitro and cellular antioxidant activity evaluation of novel peptides derived from Saccharomyces cerevisiae protein hydrolysate: structure-function relationship : Antioxidant activity and synthetic peptides

Autor:	Mahta Mirzaei, Saeed Mirdamadi, Mahnaz Mazaheri Asadi, Davood Zare, Maliheh Safavi, Mahnaz Hadizadeh
Rok vydání:	2019
Předmět:	0301 basic medicine Antioxidant Saccharomyces cerevisiae Proteins DPPH Cell Survival Protein Hydrolysates Linoleic acid medicine.medical_treatment Clinical Biochemistry Peptide Saccharomyces cerevisiae In Vitro Techniques Biochemistry Hydrolysate Antioxidants 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship medicine Humans chemistry.chemical_classification ABTS 030102 biochemistry & molecular biology biology Organic Chemistry Malondialdehyde Peptide Fragments Oxidative Stress 030104 developmental biology chemistry Catalase biology.protein Lipid Peroxidation Caco-2 Cells Oxidation-Reduction
Zdroj:	Amino acids. 51(8)
ISSN:	1438-2199
Popis:	The relationship between structure and function of primary antioxidant peptide, YR-10 (YGKPVAVPAR) was considered by synthesizing three analogues including YHR-10 (YGKHVAVHAR), GA-8 (GKPVAVPA) and PAR-3 (PAR). Antioxidant activity was determined through in vitro and cellular assays. Substitution of Pro with His in the structure of YR-10 led to significant (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994024416887776d3b7742a3cd3297a0 https://pubmed.ncbi.nlm.nih.gov/31209576 Zobrazit plný text záznamu Full text from SpringerLink