Evaluation and follow-up of pediatric COVID-19 in terms of cardiac involvement: A scientific statement from the Association of Turkish Pediatric Cardiology and Pediatric Cardiac Surgery

Autor: Yakup Ergül, Gülendam Koçak, Ahmet Çelebi, Ali Can Hatemi, Niyazi Kürşad Tokel, Kemal Nisli, H. Ercan Tutar
Rok vydání: 2020
Předmět:
Zdroj: Anatolian Journal of Cardiology
Anatolian Journal of Cardiology, Vol 24, Iss 1, Pp 13-18 (2020)
ISSN: 2149-2271
Popis: Background and Aim: The new coronavirus (SARS-COV-2) pandemic has rapidly spread to many countries and caused morbidity and mortality all over the world Central nervous system (CNS) can be affected in this disease because of the coronavirus capability to invade brainsteam Olfactorial neurons blame to be entry for neuroinvasion and the spread the infection to the brainsteam via transneural route Medulla oblangata contains cardiac, respiratory and vasomotor centers A quarter of admitted COVID-19 complain from anosmia (loss sense of smell) and which may be indicator of CNS involvement Heart rate variability (HRV) has long been associated to be a surrogate markers of cardiac autonomic tone Inflammatory bowel disease (IBD) has effects on neural cardiovascular control mechanisms the effect of IBD disease status on cardiovascular autonomic functions by measuring (HRV) parameters with 24-hour holter electrocardiogram (ECG) recording The aim of this study was to evaluate the heart rate variability (HRV) in a patient with coronavirus disease 2019 (COVID-19) as a marker disease severity and CNS involvement Methods: A prospective analytical case control study was conducted in Health Science University, Tepecik Education and Research Hospital Izmir, Turkey We enrolled 50 patients with COVID-19 and 54 matched control subjects in the study All participants underwent a 24-hour Holter recording to assess HRV parameters Firstly, we design two groups as patient and controle group Than the study population was separated into 3 groups of symptomatic disease, asymptomatic disease and control group to analyse the effect of disease severity on the HRV parameters Results: Age and gender distribution were well matched between groups (38 5±8 46 vs 39 9±15 3;p=0 95) Disease duration was 10 46±4 67 and %26 5 of patient complained from lost sense of smell and taste %50 of the COVID-19 patient had symptomatic disease on admission Control patient have higher BMI (26 2±3 34 vs 28 1±4 0;p=0 02) than COVID patients Plasma CRP (2 88±4 2 vs 0 63±1 12 p=0 003) levels were found significantly high in patient with COVID-19 No difference was determined between the COVID-19 and control groups in respect of any HRV parameters (Table 2) Significant differences were found both between the symptomatic patients and the control group and between symptomatic and asymptomatic patients in terms of the HRV measurements of SDANN5, RMSSD, CCVLF, LF/HF (Table 3) Conclusions: The results of this study demonstrated for the first time that the disease severity and symptom status in COVID-19 patients is associated with cardiac autonomic abnormalities compared to both a control groups and asymptomatic COVID-19 patients Patients who have had symptomatic COVID-19 infection appear to be at risk for arrhythmia, particularly patient with sign of CNS involvement Further research is needed to clarify long term effect of COVID-19 infection on HRV
Databáze: OpenAIRE
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