Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients
| Autor: | A. F. Panasyuk, T. M. Trofimova, J. V. Khokhlova, M. D. Grozdova, N. G. Guseva |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Adolescent Epinephrine Immunology chemistry.chemical_element Calcium Arthritis Rheumatoid stomatognathic system Rheumatology Internal medicine Cyclic AMP medicine Humans Immunology and Allergy Pharmacology (medical) Nucleotide Cyclic GMP Cells Cultured Skin chemistry.chemical_classification Scleroderma Systemic business.industry Progressive systemic sclerosis Biological Transport Fibroblasts Middle Aged medicine.disease Propranolol eye diseases stomatognathic diseases Endocrinology chemistry Rheumatoid arthritis Female Collagen business |
| Zdroj: | Arthritis & Rheumatism. 27:1144-1149 |
| ISSN: | 1529-0131 0004-3591 |
| Popis: | Levels of cAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrine-induced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was abnormal in PSS cells. Considerable heterogeneity was observed in rheumatoid arthritis fibroblasts. Membrane-bound abnormalities in (PSS) cells may be of importance in the defective control of collagen production in progressive systemic sclerosis. |
| Databáze: | OpenAIRE |
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