Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β‐tricalcium phosphate granular cement
| Autor: | Naito Kurio, Kunio Ishikawa, Youji Miyamoto, Kumiko Kamada, Yoshihide Mori, Naoyuki Fukuda, Kazuya Akita |
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| Rok vydání: | 2019 |
| Předmět: |
Calcium Phosphates
Materials science Dicalcium phosphate dihydrate Biomedical Engineering chemistry.chemical_element 02 engineering and technology Calcium Biomaterials 03 medical and health sciences chemistry.chemical_compound self-setting Materials Testing Ultimate tensile strength Mole Animals Porosity 030304 developmental biology Cement 0303 health sciences β tricalcium phosphate Skull Bone Cements 021001 nanoscience & nanotechnology Phosphate β-tricalcium phosphate dicalcium phosphate dihydrate Rats granular cement chemistry 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:22-29 |
| ISSN: | 1552-4981 1552-4973 |
| Popis: | Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0-600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20-600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:22-29, 2020. |
| Databáze: | OpenAIRE |
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