The diagnosis and management of the haematologic manifestations of lupus
| Autor: | David A. Isenberg, Sara Guerreiro Castro, Alba Velo-Garcia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Anemia medicine.medical_treatment Immunology 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Disease management (health) skin and connective tissue diseases Intensive care medicine 030203 arthritis & rheumatology Hemostasis Systemic lupus erythematosus Leukopenia business.industry Disease Management Immunosuppression Retrospective cohort study medicine.disease Thrombocytopenia Clinical trial Phenotype Anemia Hemolytic Autoimmune medicine.symptom business |
| Zdroj: | Journal of Autoimmunity. 74:139-160 |
| ISSN: | 0896-8411 |
| DOI: | 10.1016/j.jaut.2016.07.001 |
| Popis: | Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe. Therefore, different treatment approaches are needed from simply keeping vigilant to significant immunosuppression. Most treatment evidence is based on case-reports or small retrospective studies, as few randomized controlled trials have been performed. The development of biological therapy has opened new possible ways to treat the most severe cases but further clinical trials are necessary. In this review we consider the most common and characteristic haematological manifestations of SLE patients, focusing on their pathogenesis and management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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