Efficacy of low dose hCG on oocyte maturity for ovarian stimulation in poor responder women undergoing intracytoplasmic sperm injection cycle: a randomized controlled trial
| Autor: | Fatemeh Hasani, Mohammad Reza Akhoond, Shabnam Khodabakhshi, Tahereh Madani, Ladan Mohammadi Yeganeh |
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| Rok vydání: | 2012 |
| Předmět: |
endocrine system
medicine.medical_treatment Stimulation Iran Chorionic Gonadotropin Intracytoplasmic sperm injection law.invention Andrology Follicle-stimulating hormone Ovulation Induction Randomized controlled trial law Follicular phase Genetics medicine Humans Prospective Studies Sperm Injections Intracytoplasmic Assisted Reproduction Technologies Prospective cohort study Metaphase reproductive and urinary physiology Genetics (clinical) urogenital system business.industry Obstetrics and Gynecology General Medicine Oocyte Recombinant Proteins Treatment Outcome medicine.anatomical_structure Reproductive Medicine Oocytes Drug Therapy Combination Female Ovulation induction Follicle Stimulating Hormone business Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 29:1213-1220 |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-012-9854-3 |
| Popis: | To investigate the effect of late follicular administration of low dose hCG on oocyte maturity in poor responding women undergoing intracytoplasmic sperm injection (ICSI).This prospective randomized pilot trial was performed on 73 poor responders undergoing ICSI, in Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. All eligible patients underwent a GnRH-a long protocol and were randomly allocated into three study groups for ovarian stimulation: groupA received recombinant FSH alone, group B received recombinant FSH supplemented by 100 IU hCG. Group C received recombinant FSH supplemented by 200 IU hCG. The main endpoint was the number of metaphase II oocytes retrieved.Of 78 poor responding patients entered to this study, 73 women were considered eligible for enrolment. Of these, 26 women were allocated to receive only recombinant FSH, 24 patients allocated to receive recombinant FSH and 100 IU hCG and 23 patients were assigned to receive recombinant FSH and 200 IU hCG. Number of oocytes retrieved were significantly higher in group B compared to group A (6.5 ± 3.3 versus 4.0 ± 2.3; P = .03). Other cycle and clinical outcomes were comparable between three groups.The present study demonstrated that adding 100 IU hCG to rFSH in a GnRH agonist cycle in poor responders improve response to stimulation whereas the number of metaphase II oocytes remains comparable between groups. The existence of a possible trend toward higher mature oocytes and lower total dosage rFSH in patients received 100 or 200 IU hCG is probably due to the small sample size that means further large clinical trials in a more homogenous population is required (clinical trial registration number; NCT01509833). |
| Databáze: | OpenAIRE |
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