Ovarian insufficiency following allogeneic hematopoietic stem cell transplantation
| Autor: | Shoko Shimizu, Hiroko Komura, Nobuaki Mitsuda, Mariko Shimizu, Tadashi Kimura, Mahiru Kawano, Yuri Etani, Kenjiro Sawada, Mariko Nakacho, Masami Inoue, Maho Sato, Yasuko Shoji, Haruna Kawaguchi, Namiko Yada-Hashimoto, Shinobu Ida, Hirohisa Kurachi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Oncology endocrine system medicine.medical_specialty Transplantation Conditioning endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Hematopoietic stem cell transplantation Primary Ovarian Insufficiency Lower risk Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology hemic and lymphatic diseases Internal medicine Outcome Assessment Health Care medicine Humans Young adult Pregnancy Estradiol business.industry Age Factors Hematopoietic Stem Cell Transplantation Obstetrics and Gynecology Ovarian Insufficiency Prognosis medicine.disease female genital diseases and pregnancy complications Surgery Transplantation surgical procedures operative 030220 oncology & carcinogenesis Female business Complication 030215 immunology |
| Zdroj: | Gynecological Endocrinology. 33:156-159 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | Ovarian insufficiency is a serious complication for young women who undergo hematopoietic stem cell transplantation (HSCT). Reduced-intensity conditioning (RIC) has been utilized more widely due to its reduced toxicity; however, there is a lack of data concerning ovarian function after HSCT with RIC. We investigated the ovarian function in patients who received HSCT with RIC, compared to those who received myeloablative conditioning (MAC). The records of 69 female patients who received allogeneic HSCT at the institution under 40 years of age at transplantation from 1991 to 2012 were retrospectively analyzed. Prevalence of ovarian insufficiency was significantly lower in patients conditioned with RIC than in those conditioned with MAC (4/27 = 14.8% for RIC and 36/42 = 85.7% for MAC, p |
| Databáze: | OpenAIRE |
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