Predicting lead relative bioavailability in peri-urban contaminated soils usingin vitrobioaccessibility assays
| Autor: | John Weber, Albert L. Juhasz, Matthew Rees, Tim Kuchel, Euan Smith, Lloyd Sansom, Allan Rofe, Ravi Naidu |
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| Přispěvatelé: | Juhasz, Albert Laszlo, Smith, Euan Robert George, Weber, John, Rees, Matthew, Kuchel, Tim, Rofe, Allan, Sansom, Lloyd Norman, Naidu, Ravendra |
| Rok vydání: | 2013 |
| Předmět: |
Environmental Engineering
Swine Biological Availability Incineration Models Biological Animals Humans Soil Pollutants Intestinal Mucosa Urban Renewal lead Contaminated soils Chemistry In vitro toxicology in vitro General Medicine relative bioavailability bioaccessibility In vitro Refuse Disposal Bioavailability in vivo Lead Gastric Mucosa Environmental chemistry Linear Models Environmental Monitoring Forecasting |
| Zdroj: | Journal of Environmental Science and Health, Part A. 48:604-611 |
| ISSN: | 1532-4117 1093-4529 |
| DOI: | 10.1080/10934529.2013.731354 |
| Popis: | In this study, lead (Pb) bioaccessibility was assessed in peri-urban contaminated soils using a variety of established in vitro assays. Bioaccessibility data was then used to predict Pb relative bioavailability (RBA) using published in vivo-in vitro regression models in order to compare calculated estimates and measured values. Lead bioaccessibility varied depending on the in vitro methodology employed with the relative bioavailability leaching procedure (RBALP) and in vitro gastrointestinal (IVG) assays providing more conservative Pb bioaccessibility values compared to those determined using PBET, UBM and Rel-SBRC-I assays. When Pb RBA was calculated, predicted values using PBET-G and UBM-G data were similar to measured Pb RBA values. However, Pb RBA was over-estimated by 1.6-5.5- and 2.6-6.6-fold when data and regression models from RBALP and IVG-G assays were employed. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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